Other medicines used in Crohn’s or Colitis
Painkillers
Speak to your IBD team or GP about which medicines are safe to use for you.
Paracetamol. You can take normal doses of paracetamol if pregnant. It has been used during pregnancy for many years without any negative effects on children. Always check with a GP or midwife before taking paracetamol if it's combined with other medicines.
Ibuprofen. The NHS does not usually recommend ibuprofen during pregnancy. Also, some evidence suggests that ibuprofen and some other non-steroidal anti-inflammatory drugs (NSAIDs), can make Crohn’s or Colitis symptoms worse. This could be more likely if your condition is active, or you take NSAIDs for a long time. But it’s difficult to know for sure.
Codeine. Codeine can be taken in pregnancy, although long-term use is not recommended. Your doctor may not prescribe codeine if you are having a flare-up of Colitis. This is because this type of medicine can increase the risk of a rare and serious complication called toxic megacolon. This is when your colon swells to a much larger size due to trapped gas caused by inflammation. This creates a risk of possible rupture and blood poisoning, or septicaemia.
Mycophenolate mofetil
This medicine is also known as the brand name CellCept.
You should not take mycophenolate mofetil during pregnancy. Use contraception while you take mycophenolate mofetil, and for six weeks after you stop treatment. Mycophenolate mofetil can cause birth defects and miscarriages.
Men should use reliable contraception when taking mycophenolate mofetil. Men should also use contraception for at least 90 days, or three months, after stopping treatment.
Ciclosporin and Tacrolimus
You should discuss the benefits and risks of taking these medicines with your IBD team.
You can take ciclosporin and tacrolimus during pregnancy if the benefits outweigh the potential risks. However, there is little data about their safety in pregnancy.
Metronidazole and Ciprofloxacin
These antibiotics are sometimes used to treat infections linked to Crohn’s or pouchitis after pouch surgery, also known as IPAA surgery. In these situations, you can take metronidazole during pregnancy.
You should not take ciprofloxacin during the first trimester.
Antidiarrhoeals
- Colestyramine, also known as the brand name Questran
- Loperamide, also known as the brand names Imodium and Arret
You can take colestyramine during pregnancy. You may develop deficiencies in some vitamins if you’re taking it long-term, so you may need extra checks or supplements.
You may be able to take loperamide during pregnancy. Talk to your IBD team first about whether the benefits outweigh the potential risks. Some studies link loperamide to birth defects. But not all studies show this. The data is not yet good enough to say whether loperamide is safe in pregnancy.
Antispasmodics
- Hyoscine butylbromide, also known by the brand name Buscopan
- Mebeverine, also known by the brand names Colofac, Colofac IBS and Aurobeverine
- Alverine citrate
- Peppermint oil
You may be able to take hyoscine butylbromide during pregnancy, but you should discuss the benefits and risks with your IBD team. It’s not thought to be harmful, but there is not enough research to confirm this.
You may be able to take mebeverine hydrochloride, alverine citrate or peppermint oil during pregnancy. But there is not enough data to know if they’re safe. Talk to your IBD team about whether the benefits outweigh the unknown risks to the baby.
Allopurinol
Allopurinol is usually taken in combination with azathioprine.
There is not much data on taking allopurinol during pregnancy. Taking allopurinol during pregnancy to prevent a flare-up may be more beneficial than the potential risks to your baby. This may be different for each person. If you want to take allopurinol, this should be discussed with your IBD team.
You can check whether a medicine is safe to take during pregnancy by searching for your medicine on the Bumps website.