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Last reviewed: January 2023
This information is for people with Ulcerative Colitis who are taking ozanimod (Zeposia). It is also for anyone who is thinking about starting treatment with ozanimod. This information can help you decide if ozanimod is right for you. It looks at:
This information is about ozanimod in general. It should not replace advice from your IBD team.
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Ozanimod is also known by the brand name Zeposia.
Ozanimod is a type of medicine called a sphingosine-1-phosphate (S1P) receptor modulator. Ozanimod attaches to a protein on some white blood cells (lymphocytes). Ozanimod stops lymphocytes from travelling around your body and causing inflammation in your gut. This reduces the symptoms of Colitis.
Ozanimod is used to treat adults with moderately to severely active Ulcerative Colitis. The aim of treatment is to get your Colitis under control and keep it under control.
Ozanimod can only be prescribed by a specialist in a hospital. Your IBD team may suggest ozanimod if you:
Standard treatments include aminosalicylates (5-ASAs), oral steroids or immunosuppressants (for example azathioprine, mercaptopurine or methotrexate).
There are lots of things to think about when you start a new treatment. Your IBD team will discuss your options with you. When thinking about a new treatment you might want to consider the potential benefits, possible risks and the goals of your treatment. Some things to think about include:
Our Appointment guide has a list of questions you might want to ask. It can help you focus on what matters most to you. You might find our information about other medicines and surgery for Colitis helpful.
Use this tool to understand more about potential treatment options that suit your needs. The tool is designed to help you:
Find out more about how we talk about the effectiveness of medicines.
Ozanimod is used to get and keep your Colitis symptoms under control (remission). Ozanimod does not work for everyone. But it can be helpful for some people if other treatments have not worked well.
A clinical trial looked at how effective ozanimod is. The trial included adults with moderate to severely active Colitis. The people in the trial were given either ozanimod or a placebo. A placebo is a dummy treatment that looks the same but does not have any medicine in it.
The table below shows how many people were in remission after taking ozanimod or a placebo after a year.
Nearly twice as many people were in remission after taking ozanimod when compared to the people taking a placebo. But ozanimod did not work for everyone.
Everyone responds differently to a new medicine. Some people start to feel better after taking ozanimod for about 10 weeks, but it may take longer.
Ozanimod comes as a tablet that you take once per day. You should swallow the tablet whole. Do not split, crush or chew the tablet because it could change how much medicine gets into your body. Ozanimod can be taken with or without food.
When you start taking ozanimod, you will take a low dose and gradually build up to the normal dose. This is to reduce some side effects such as a low heart rate.
To gradually build up to the normal dose, you will be given a ‘treatment induction pack.’ This is a pre-prepared pack with labelled tablets that you will take for the first seven days.
It has:
You should then have finished the induction pack of tablets.
On day eight of treatment, you will start taking tablets from a ‘maintenance pack.’ This pack has tablets containing the normal dose of ozanimod. From day eight onwards, you will take one of these tablets each day.
Day 1 |
Day 2 |
Day 3 |
Day 4 |
Day 5 |
Day 6 |
Day 7 |
Day 8 |
Continue taking every day |
One 0.23mg tablet |
One 0.23mg tablet |
One 0.23mg tablet |
One 0.23mg tablet |
One 0.46mg tablet |
One 0.46mg tablet |
One 0.46mg tablet |
One 0.92mg tablet |
One 0.92mg tablet |
Let your IBD team know if you forget to take a dose of ozanimod or miss a dose during your first 14 days of treatment. You may need to start the treatment induction pack again.
You are likely to have a planned course of treatment for one year. After that, your treatment plan may be extended. Your IBD team will continue to check that ozanimod is still working well for you.
There are a few reasons why you or your IBD team might think about stopping or changing your treatment:
You will have regular checks to see if your Colitis is improving and ozanimod is working for you. If it is not working well, your IBD team might suggest stopping ozanimod and trying a different treatment.
You should not stop taking ozanimod without informing your IBD team.
Your IBD team will let you know if you need to take other medicines for your Colitis. You may have to start or continue to take steroids or 5-ASAs alongside ozanimod.
Because ozanimod can affect your immune system, it should not be taken with other immunosuppressants such as azathioprine and mercaptopurine.
Clinical trials have not looked at whether it is safe to take ozanimod alongside biologic medicines.
Before you start taking ozanimod, your IBD team may offer some tests to check that it is the right treatment for you. They are likely to:
Some other checks you might need are:
Ozanimod can cause a slow heart rate in some people. Before you start taking ozanimod, you will have your heart checked. This is done using a test called an electrocardiogram (ECG).
If you have a slow heart rate or certain heart conditions, your doctor will also monitor you for at least six hours after your first dose of ozanimod, checking your pulse and blood pressure every hour. You may also need an ECG six hours after you have taken ozanimod.
An uncommon side effect of ozanimod is blurred vision. If you have diabetes or a history of eye problems such as uveitis, you may need to have an eye examination before starting ozanimod.
While taking ozanimod, your IBD team will check how well it is working.
You will have:
Your IBD team will let you know when these checks are needed. They will also ask about your Colitis symptoms and any side effects that you are getting.
Ozanimod may increase your risk of skin cancer. You should protect your skin from the sun by wearing protective clothing. Applying sunscreen regularly and staying in the shade can also protect your skin. Visit the NHS website for tips on staying safe in the sun.
All medicines can have side effects, although not everyone will get them. Some side effects can happen right away, others may happen later. Some can even last for a short time after you stop treatment.
Some side effects are mild and may go away on their own or after you stop taking ozanimod. Others may be more serious and could need treatment. Some side effects might mean that ozanimod is not right for you.
Some serious side effects may need urgent treatment. Tell your GP or IBD team if you get any of the following side effects:
Ozanimod affects your immune system. This means that while you are taking ozanimod, your body may get infections more easily. You might get more infections than you used to. Or they might last longer or be more serious than usual.
More than 1 in 10 people taking ozanimod may get an infection of their nose or nostrils, mouth or throat. Up to 1 in 10 people taking ozanimod may get a urinary tract infection (UTI).
If you think you have an infection, contact your GP for treatment and let your IBD team know.
Some symptoms of infection to look out for include:
If you have an infection, your doctor may ask you to stop taking ozanimod until you feel better.
The signs and symptoms of a medicine allergy usually occur soon after taking the medicine. But serious allergic reactions are uncommon. Up to 1 in every 100 people taking ozanimod may have an allergic reaction.
Call 999 or emergency medical help if you think you are having a severe allergic reaction.
Signs to look out for include:
The patient information leaflet (PIL) that comes with your medicine also has a full list of potential side effects. You can also download the leaflet online from medicines.org.uk.
Let your IBD team know if you get any side effects while taking ozanimod.
We encourage you to report any side effects to the Medicines and Healthcare Products Regulatory Agency (MHRA) through the Yellow Card scheme. Your doctor should also report it. Report your side effect at yellowcard.mhra.gov.uk.
Tell your doctor, IBD team or pharmacist about any other medicines you are taking or thinking of taking. This includes:
Some medicines can affect the way ozanimod works.
Before taking ozanimod, tell your doctor or pharmacist if you are taking, or have recently taken, any of the following medicines:
Your IBD team will check that your vaccinations are up to date before you start treatment with ozanimod. This may include the shingles vaccine, chickenpox vaccine and BCG.
Live vaccines used in the UK include:
If anyone in your family or household is due to have a live vaccine, check with your IBD team whether you need to take any special precautions.
The flu, pneumococcal and COVID-19 vaccines are not live vaccines and are safe to have while you are taking ozanimod.
Let your IBD team know immediately if you are taking ozanimod and you become pregnant or you think you might be pregnant. They will be able to discuss the next steps with you.
You should not use ozanimod if you are pregnant or breastfeeding. If used during pregnancy, ozanimod can harm the unborn baby. Potential risks include loss of the unborn baby and birth defects.
Before starting treatment with ozanimod:
If you are planning to get pregnant, speak with your IBD team as soon as possible. You should stop taking ozanimod 3 months before planning a pregnancy. This will allow time to review your treatment options and make sure your Colitis is controlled as well as possible.
There has not been any research into whether ozanimod affects male or female fertility in humans yet. In studies with animals, ozanimod was not found to have any effect on fertility.
Read our information on pregnancy and reproductive health.
Ozanimod can pass into breast milk. It is not yet known how this could affect your baby. You should not take ozanimod if you are breastfeeding.
Read our information on pregnancy and breastfeeding.
Alcohol is not known to interact with ozanimod. Ask your IBD team about drinking alcohol while taking ozanimod. To keep the health risks from drinking alcohol low it is best to stay within the recommended limits.
Taking medicines and managing side effects can be difficult – we understand and we’re here to help. Our Helpline can answer general questions about treatment options and can help you find support from others with the conditions.
Your IBD team are also there to help. You can talk to them about your dosage, how they’ll be monitoring you and what alternatives may be available. You should also get in touch with your IBD team if you have any new symptoms or side effects.
It can take time to find the medicine that’s right for you. Don’t be afraid to ask questions and seek out extra support when you need it.
This information is general and doesn’t replace specific advice from your health professional. Talk to your doctor or IBD team for more information.
We follow strict processes to make sure our information is based on up-to-date evidence and easy to understand.
Please email us at evidence@crohnsandcolitis.org.uk if:
You can also write to us at Crohn’s & Colitis UK, 1 Bishop Square, Hatfield, AL10 9NE, or contact us through our Helpline: 0300 222 5700
We know it can be difficult to live with, or support someone living with these conditions. But you’re not alone. We provide up-to-date, evidence-based information and can support you to live well with Crohn’s or Colitis.
Our helpline team can help by:
Providing information about Crohn’s and Colitis.
Listening and talking through your situation.
Helping you to find support from others in the Crohn’s and Colitis community.
Providing details of other specialist organisations.
Please be aware we’re not medically or legally trained. We cannot provide detailed financial or benefits advice or specialist emotional support.
Please contact us via telephone, email or LiveChat - 9am to 5pm, Monday to Friday (except English bank holidays).
If you need specific medical advice about your condition, your GP or IBD team will be best placed to help.
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