Can testing stool samples in children help determine choice of treatment?


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Investigating how different treatments affect IBD markers in stool samples of children. 


We hope to improve the quality of life of children with Crohn’s Disease by using a simple test to assess their response to treatment.

Astor Rodrigues, John Radcliffe Hospital, Oxford

What is this research looking at?

Testing stool for markers of inflammation has boosted our ability to diagnose Crohn’s Disease early in children. While effective treatments exist, some children need to try several different types before they find the one that works for them. This has an adverse effect on their quality of life, and risks the development of complications. A simple test that could determine whether or not a treatment was working soon after it was started would allow clinicians to identify children that need to be put on stronger treatments earlier. We propose that the same tests for inflammation could be used for this purpose and that parents could collect samples at home.

What do the researchers think this could mean for people with IBD?

This research will hopefully enable faster and more personalised treatment for children with IBD.

Who is leading this research? Dr Astor Rodrigues, John Radcliffe Hospital/University of Oxford

Project cost: £10,000 (jointly funded by BSPGHAN

Duration: 18 months

Official title of application: Early measurement of faecal calprotectin as a predictor of primary non-response to treatment in paediatric Crohn’s Disease: a pilot study (PSG16-3)