Statement on TPN shortages

19 August 2019

Calea UK are currently unable to deliver total parenteral nutrition (TPN) bags to a significant number of UK patients, affecting some with Crohn's or Colitis.

Between 24-26 June 2019 the Medicines and Healthcare products Regulatory Agency (MHRA), an organisation that makes sure that medicines and medical devices work and are safe in the UK, inspected the factory of Calea UK, a supplier of total parenteral nutrition (TPN).

The inspection found that although there were no contaminated products, the changes insisted by MHRA to Calea’s manufacturing process were immediate and essential. This has meant that Calea are unable to deliver TPN to a significant number of patients, which NHS England have called a ‘national emergency’.

A national working group involving healthcare professionals, experts and officials from NHS England and the Department of Health and Social Care are working with suppliers to find other ways to increase the supply of TPN and resolve this situation as soon as possible. 


Crohn’s & Colitis UK is here for everyone living with Crohn’s and Colitis who has been affected by this situation and it is vital that all possible avenues are explored to make sure that the disruption to supplies is fixed quickly and safely.

We’re deeply concerned to hear that people receiving TPN have been given ‘off the shelf’ bags which could have unpleasant and unsafe side effects or have been without TPN at all.


If you or your child has been affected, we recommend taking the following action, which has also been advised by PINNT, a support group for people receiving home artificial nutrition:

  • Speak to your/ your child’s doctor and other relevant healthcare professional to let them know if you have issues with receiving TPN or any fluids you are expecting
  • Keep in regular contact with Calea UK
  • Contact your local MP

For more information, read PINNT’s full statement (pdf) and this government news story

We will keep you updated as this story develops.